Depression is a common symptom in many older adults. The degree of depression is high between older adults living in sanitarium than older adults those living in the society. Moreover, the amount of this disorder is higher between females than males. Reminiscence therapy is a psychological intervention which is specifically designed to address the issues of particular relevance to older adults such as depression. The aim of this study was to examine the therapeutic effectiveness of integrative and instrumental type of reminiscence for the treatment of depression in institutionalized older adults’ women in Kermanshah. This study was experimental one with a pretest and posttest control group design. Institutionalized older adults’ women with mild, moderate to severe symptom constituted the sample. They were randomly assigned into three groups containing two experimental (instrumental and integrative reminiscence) and one control group (active social group).The intervention were implemented in a short-time group format. For each group six sessions were applied. Each session was held minutes weekly. The instruments were Geriatric Depression Scale (GDP) and Mini Mental State Examination (MMSE). The collected data were analyzed through analysis of variance (ANOVA). The results showed that integrative and instrumental reminiscence therapies led to significant reduction in symptoms of depression (P ).The difference between two experimental groups were not however statistically significant. Based on the findings of this study, it can be concluded that integrative and instrumental therapy can be applied along with current therapies